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Editorial Reviews

A master storyteller (whether he opens his mouth or not), Norman Blake's grace, subtlety, and facility - both verbal and instrumental - have had a powerful influence on three generations of acoustic musicians. From his own magical solo records to his sessions with Steve Earle, Bob Dylan, and Tony Rice (which won an IBMA award), Norman Blake is one of the most distinct voices of the flat-picked acoustic guitar. As a songwriter, his songs have found their way into albums by such luminaries as the New Grass Revival, the Tony Rice Unit and the Seldom Scene. Blackberry Blossom, first released in 1977, finds his songwriting and instrumental ability equally sharp. Be it lickity-split single note runs, rock-solid rhythmic strumming, or a masterful combination of both, his flat-picking is peerless. And his songs - dripping with bittersweet evocations of rural America - are utterly enchanting. Nancy Blake, playing cello and guitar, adds an elegance and stateliness to one of Norman's strongest and most varied collections.

Blackberry Blossom

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Next-Generation Sequencing Drives Progress in Biopharma

Bioscience is a vast puzzle, which sounds like fun—until you remember that puzzles can be frustrating, especially if they’re missing crucial pieces. Fortunately, as this issue of GEN indicates, some of bioscience’s missing pieces are falling into place. Piece one: The tissue-level patterns formed by cells with disparate gene expression profiles. (These patterns, which influence health, are emerging because single-cell technology is being combined with spatial transcriptomics.) Piece two: A smooth Design-Build-Test-Learn (DBTL) cycle in synthetic biology. (DBTL still isn’t turning as freely as it might, but with new DNA-writing technology, more RPMs are expected.) Piece three: CAR T cells that could help more than a minority of cancer patients. (Such cells may be built if allogeneic approaches are used, or if genetic engineering is used to install ancillary immune signals.) So, if you want to solve bioscience puzzles—including those related to outsourcing and bringing NGS to bear in biomanufacturing—read our September issue.

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